Article
Elevated p53 protein expression; a predictor of relapse in rare chronic myeloid malignancies in children?
Pediatric hematology and oncology - 1 May 2014
Honkaniemi Emma, Mattsson Kristin, Barbany Gisela, Sander Birgitta, Gustafsson Britt
Abstract excerpt
BACKGROUND: Alterations in the tumor suppressor gene TP53 have been associated with poor outcome in adult hematological malignancies. We have earlier reported an increased expression of the TP53 encoded protein p53, in bone marrow samples from pediatric patients with aggressive leukemia. Our aim was now to evaluate p53 protein expression at different time points before and after hematopoietic stem cell...
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