[Molecular analysis of tumor suppressor genes p16INK4 and TP53 of osteosarcomas in Spanish children].

Abstract excerpt

OBJECTIVE: Alterations affecting tumor suppressor genes, specifically p16INK4 and TP53, have been shown to be involved in the development of human cancer due to their important role in the control of normal cell cycle progression. As the genetic events leading to the development of pediatric osteosarcoma remain partially unclear, we have tested the possibility that a significant number of pediatric osteosarcoma...

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