Analysis of the p53 gene by PCR-SSCP in ten cases of Wilms' tumor.

doi:10.1590/s1516-31802000000200005

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Article

Analysis of the p53 gene by PCR-SSCP in ten cases of Wilms' tumor.

Sao Paulo medical journal = Revista paulista de medicina - 2 Mar 2000

Defavery R, Lemos J A, Kashima S, Bernardes J E, Scridelli C A, Covas D T, Tone L G

Abstract excerpt

CONTEXT: Mutations of the p53 tumor suppressor gene are the most frequent alterations observed in human neoplasias affecting adults. In pediatric oncology, however, they have seldom been identified. Wilms' tumor is a renal neoplasia commonly occurring in children and is associated with mutations of the WT1 gene. The correlation between Wilms' tumor and alterations of the p53 gene has not been well established,...

Topics

Child
Child, Preschool
Female
Genes, Wilms Tumor
Genes, p53
Humans
Infant
Kidney Neoplasms
Male
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Sequence Analysis, DNA
Wilms Tumor

Source

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Identifiers

PMID: 10772697
DOI: 10.1590/s1516-31802000000200005
PMCID: PMC11166235

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