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Article

Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization.

Genes & development - 15 Mar 2003

Gribnau Joost, Hochedlinger Konrad, Hata Ken, Li En, Jaenisch Rudolf

Abstract excerpt

Genomic imprinting in mammals marks the two parental alleles resulting in differential gene expression. Imprinted loci are characterized by distinct epigenetic modifications such as differential DNA methylation and asynchronous replication timing. To determine the role of DNA methylation in replication timing of imprinted loci, we analyzed replication timing in Dnmt1- and Dnmt3L-deficient embryonic stem (ES)...

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Identifiers

PMID: 12651894
DOI: 10.1101/gad.1059603
PMCID: PMC196021

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