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Article

CTCF regulates asynchronous replication of the imprinted H19/Igf2 domain.

Cell cycle (Georgetown, Tex.) - 15 Feb 2007

Bergström Rosita, Whitehead Joanne, Kurukuti Sreenivasulu, Ohlsson Rolf

Abstract excerpt

Asynchronous replication during S phase is a universal characteristic of genomically imprinted genes. Replication timing in imprinted domains is determined epigenetically, as it is parent of origin specific, and is seen in the absence of sequence divergence between the two alleles. At the imprinted H19/Igf2 domain, the methylated paternal allele replicates early while the CTCF-bound maternal allele replicates...

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Share to CCCTC-Binding Factor
Share to Chromosomes, Mammalian
Share to Genomic Imprinting

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Inheritance Patterns

Share to Insulin-Like Growth Factor II

Share to RNA, Long Noncoding

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Source

Identifiers

PMID: 17329968
DOI: 10.4161/cc.6.4.3854

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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CTCF regulates asynchronous replication of the imprinted H19/Igf2 domain.PMID 17329968Read ↗

Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization.Semantic proximity Read ↗

Allele-specific replication timing of imprinted gene regions.Semantic proximity Read ↗

Paternal imprints can be established on the maternal Igf2-H19 locus without altering replication timing of DNA.Semantic proximity Read ↗

CTCF binding sites promote transcription initiation and prevent DNA methylation on the maternal allele at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

Imprinting mutations in the Beckwith—Wiedemann syndrome suggested by an altered imprinting pattern in the <i>IGF2–H19</i> domainSemantic proximity Read ↗

Asynchronous replication of imprinted genes is established in the gametes and maintained during development.Semantic proximity Read ↗

Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development.Semantic proximity Read ↗

Expression of H19 does not influence the timing of replication of the Igf2/H19 imprinted region.Semantic proximity Read ↗

Parent-of-origin-specific DNA replication timing is confined to large imprinted regions.Semantic proximity Read ↗

Replication timing properties within the mouse distal chromosome 7 imprinting cluster.Semantic proximity Read ↗

Allele-specific genome-wide profiling in human primary erythroblasts reveal replication program organization.Semantic proximity Read ↗

CTCF binding at the <i>H19</i> imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to <i>Igf2</i>Semantic proximity Read ↗

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