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Article

Aggregate formation and the impairment of long-term synaptic facilitation by ectopic expression of mutant huntingtin in Aplysia neurons.

Journal of neurochemistry - 1 Apr 2003

Lee Jin-A, Lim Chae-Seok, Lee Seung-Hee, Kim Hyoung, Nukina Nobuyuki, Kaang Bong-Kiun

Abstract excerpt

Huntington's disease (HD) is caused by an expansion of a polyglutamine (polyQ) tract within huntingtin (htt) protein. To examine the cytotoxic effects of polyQ-expanded htt, we overexpressed an enhanced green fluorescent protein (EGFP)-tagged N-terminal fragment of htt with 150 glutamine residues (Nhtt150Q-EGFP) in Aplysia neurons. A combined confocal and electron microscopic study showed that Aplysia neurons...

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Identifiers

PMID: 12641738
DOI: 10.1046/j.1471-4159.2003.01650.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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