Article

Sonicated fibrils of huntingtin exon-1 preferentially seed neurons and produce toxic assemblies

2021-04-18

Abstract excerpt

Huntington’s disease (HD) is a genetically inherited neurodegenerative disorder caused by expansion of a polyglutamine (polyQ) repeats in the exon-1 of huntingtin protein (HTT). The expanded polyQ enhances the amyloidogenic propensity of HTT exon 1 (HTTex1), which forms a heterogeneous mixture of assemblies with some being neurotoxic. While predominantly intracellular, monomeric and aggregated mutant HTT species a...

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Literature Corpus work: fc7c99c0-1e0f-5b97-bc91-8c65769d7731
DOI: 10.1101/2021.04.16.440200

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