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Article

Differential effects of soluble and aggregating polyQ proteins on cytotoxicity and type-1 myosin-dependent endocytosis in yeast.

Scientific reports - 12 Sept 2017

Berglund Lisa L, Hao Xinxin, Liu Beidong, Grantham Julie, Nyström Thomas

Abstract excerpt

Huntington's disease develops when the polyglutamine (polyQ) repeat in the Huntingtin (Htt) protein is expanded to over 35 glutamines rendering it aggregation-prone. Here, using Htt exon-1 as a polyQ model protein in a genome-wide screen in yeast, we show that the normal and soluble Htt exon-1 is toxic in cells with defects in type-1 myosin-dependent endocytosis. The toxicity of Htt is linked to physical...

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Identifiers

PMID: 28900136
DOI: 10.1038/s41598-017-11102-6
PMCID: PMC5595923

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