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Article

Amplification of neurotoxic HTTex1 assemblies in human neurons.

Neurobiology of disease - 1 Nov 2021

Chongtham Anjalika, Isas J Mario, Pandey Nitin K, Rawat Anoop, Yoo Jung Hyun, Mastro Tara, Kennedy Mary B, Langen Ralf, Khoshnan Ali

Abstract excerpt

Huntington's disease (HD) is a genetically inherited neurodegenerative disorder caused by expansion of a polyglutamine (polyQ) repeat in the exon-1 of huntingtin protein (HTT). The expanded polyQ enhances the amyloidogenic propensity of HTT exon 1 (HTTex1), which forms a heterogeneous mixture of assemblies with a broad neurotoxicity spectrum. While predominantly intracellular, monomeric and aggregated mutant HTT...

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Amyloidogenic Proteins
Astrocytes
Caspase 3
Gene Knock-In Techniques
Huntingtin Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Huntington Disease

Protein Aggregation, Pathological

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Identifiers

PMID: 34563643
DOI: 10.1016/j.nbd.2021.105517
PMCID: PMC8943833

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