Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polyglutamine Diseases and Transport Problems

1 Jan 2005

Abstract excerpt

The expansion of CAG repeats encoding glutamine (polyQ) causes, to date, 9 late-onset progressive neurodegenerative disorders, including Huntington disease, spinobulbar muscular atrophy, dentatorubral-pallidoluysian atrophy, and spinocerebellar ataxias 1, 2, 3, 6, 7, and 17. Although many studies using both knockout and transgenic mouse models suggest that a toxic gain of function is central to neuronal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Neurodegenerative Diseases
Share to Mitochondrial Function and Pathology
Share to Neurological disorders and treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15642849
DOI: 10.1001/archneur.62.1.46

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polyglutamine Diseases and Transport ProblemsPMID 15642849Read ↗

The pathogenic mechanisms of polyglutamine diseases and current therapeutic strategies.Semantic proximity Read ↗

Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative DiseaseSemantic proximity Read ↗

Polyglutamine Diseases: Where does Toxicity Come from? What is Toxicity? Where are We Going?Semantic proximity Read ↗

Protein Aggregation and Pathogenesis of Huntingtons Disease: Mechanisms and CorrelationsSemantic proximity Read ↗

Neurotoxic protein oligomerisation associated with polyglutamine diseases.Semantic proximity Read ↗

Pathogenesis of polyglutamine disorders: aggregation revisitedSemantic proximity Read ↗

Polyglutamine (PolyQ) Diseases: Genetics to TreatmentsSemantic proximity Read ↗

Polyglutamine aggregation in Huntington and related diseases.Semantic proximity Read ↗

Toward an understanding of polyglutamine neurodegeneration.Semantic proximity Read ↗

Polyglutamine (PolyQ) Diseases: Navigating the Landscape of NeurodegenerationSemantic proximity Read ↗

Nucleo–cytoplasmic transport defects and protein aggregates in neurodegenerationSemantic proximity Read ↗

Aberrant Protein Deposition and Neurological DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.