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Article

Ultrastructural localization and progressive formation of neuropil aggregates in Huntington's disease transgenic mice

1 Jul 1999

Abstract excerpt

How aggregates of polyglutamine proteins are involved in the neurological symptoms of glutamine repeat diseases is unknown. We show that huntingtin aggregates are present in the neuronal processes of transgenic mice that express exon 1 of the Huntington's disease (HD) gene. Unlike aggregates in the nucleus, these neuropil aggregates are usually smaller and are not ubiquitinated. Electron microscopy reveals many...

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PMID: 10369868
DOI: 10.1093/hmg/8.7.1227

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