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Article

Soluble N-terminal fragment of mutant Huntingtin protein impairs mitochondrial axonal transport in cultured hippocampal neurons.

Neuroscience bulletin - 1 Feb 2014

Tian Jun, Yan Ya-Ping, Zhou Rui, Lou Hui-Fang, Rong Ye, Zhang Bao-Rong

Abstract excerpt

Huntington's disease (HD) is an autosomal dominant, progressive, neurodegenerative disorder caused by an unstable expansion of CAG repeats (>35 repeats) within exon 1 of the interesting transcript 15 (IT15) gene. This gene encodes a protein called Huntingtin (Htt), and mutation of the gene results in a polyglutamine (polyQ) near the N-terminus of Htt. The N-terminal fragments of mutant Htt (mHtt), which tend to...

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Identifiers

PMID: 24362588
DOI: 10.1007/s12264-013-1393-0
PMCID: PMC5562578

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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