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Article

Mutant Huntingtin Disrupts the Nuclear Pore Complex.

Neuron - 5 Apr 2017

Grima Jonathan C, Daigle J Gavin, Arbez Nicolas, Cunningham Kathleen C, Zhang Ke, Ochaba Joseph, Geater Charlene, Morozko Eva, Stocksdale Jennifer, Glatzer Jenna C, Pham Jacqueline T, Ahmed Ishrat, Peng Qi, Wadhwa Harsh, Pletnikova Olga, Troncoso Juan C, Duan Wenzhen, Snyder Solomon H, Ranum Laura P W, Thompson Leslie M, Lloyd Thomas E, Ross Christopher A, Rothstein Jeffrey D

Abstract excerpt

Huntington's disease (HD) is caused by an expanded CAG repeat in the Huntingtin (HTT) gene. The mechanism(s) by which mutant HTT (mHTT) causes disease is unclear. Nucleocytoplasmic transport, the trafficking of macromolecules between the nucleus and cytoplasm, is tightly regulated by nuclear pore complexes (NPCs) made up of nucleoporins (NUPs). Previous studies offered clues that mHTT may disrupt...

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Identifiers

PMID: 28384479
DOI: 10.1016/j.neuron.2017.03.023
PMCID: PMC5595097

Genes

HTT
RAN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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