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Article

Effects of flanking sequences and cellular context on subcellular behavior and pathology of mutant HTT.

Human molecular genetics - 13 Mar 2020

Chongtham Anjalika, Bornemann Douglas J, Barbaro Brett A, Lukacsovich Tamas, Agrawal Namita, Syed Adeela, Worthge Shane, Purcell Judith, Burke John, Chin Theodore M, Marsh J Lawrence

Abstract excerpt

Huntington's disease (HD) is caused by an expansion of a poly glutamine (polyQ) stretch in the huntingtin protein (HTT) that is necessary to cause pathology and formation of HTT aggregates. Here we ask whether expanded polyQ is sufficient to cause pathology and aggregate formation. By addressing the sufficiency question, one can identify cellular processes and structural parameters that influence HD pathology and...

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Identifiers

PMID: 31943010
DOI: 10.1093/hmg/ddaa001
PMCID: PMC7608755

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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