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Article

Alterations of anaphase-promoting complex genes in human colon cancer cells.

Oncogene - 13 Mar 2003

Wang Qing, Moyret-Lalle Caroline, Couzon Florence, Surbiguet-Clippe Christine, Saurin Jean-Christophe, Lorca Thierry, Navarro Claudine, Puisieux Alain

Abstract excerpt

Ubiquitin-mediated proteolysis of cell cycle regulators is a major element of the cell cycle control. The anaphase-promoting complex (APC/C) is a large multisubunit ubiquitin-protein ligase required for the ubiquitination and degradation of G1 and mitotic checkpoint regulators. APC/C-dependent proteolysis regulates cyclin levels in G1, and triggers the separation of sister chromatids at the metaphase-anaphase...

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Source

Identifiers

PMID: 12629511
DOI: 10.1038/sj.onc.1206224

Genes

APC
CDC23
CDC16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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