Article
Characterization of the Apc10/Doc1 subunit of the anaphase promoting complex in Drosophila melanogaster.
Acta biologica Hungarica - 1 Jan 2007
Pál Margit, Varga Kata, Nagy Olga, Deák P
Abstract excerpt
The anaphase promoting complex or cyclosome (APC/C) is a large protein complex with an ubiquitin ligase activity which specifically targets mitotic regulatory proteins for proteasomal degradation. The APC/C contains at least 11 subunits, most of which are evolutionarily conserved from yeasts to humans. We have isolated and characterized mutant alleles of the gene that codes for the APC10/Doc1 subunit of the...
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