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Article

CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability.

Cancer research - 15 Dec 2005

Kemp Zoe, Rowan Andrew, Chambers William, Wortham Noel, Halford Sarah, Sieber Oliver, Mortensen Neil, von Herbay Axel, Gunther Thomas, Ilyas Mohammad, Tomlinson Ian

Abstract excerpt

CDC4/FBXW7 is part of a ubiquitin ligase complex which targets molecules such as cyclin E, c-myc, and c-jun for destruction. CDC4 mutations occur in several cancer types and are best described in colorectal tumors. Knockout of CDC4 in vitro in colorectal cancer cells causes changes suggestive of chromosomal instability (CIN). In p53(+/-) mice, radiation-induced lymphomas show deletion or mutation of one copy of...

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PMID: 16357143
DOI: 10.1158/0008-5472.CAN-05-2565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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