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Article

Comparison of genetic alterations in colonic adenoma and ulcerative colitis-associated dysplasia and carcinoma

1 Feb 1998

Abstract excerpt

Carcinoma is an important complication of ulcerative colitis (UC) and develops from dysplastic precursor lesions. Genetic changes involved in the malignant transformation have not been fully characterized. We studied 19 cases of UC with high-grade dysplasia (HGD) and eight samples of associated carcinoma (CA). Microdissection of normal epithelium, epithelium at the site of chronic inflammation, HGD, and CA was...

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PMID: 9490271
DOI: 10.1016/s0046-8177(98)90222-2

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