Article
Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability.
Proceedings of the National Academy of Sciences of the United States of America - 22 Mar 2005
Rao Chinthalapally V, Yang Yang-Ming, Swamy Malisetty V, Liu Tongyi, Fang Yuqiang, Mahmood Radma, Jhanwar-Uniyal Meena, Dai Wei
Abstract excerpt
Faithful chromosome segregation is essential for the maintenance of genetic stability during cell division and it is at least partly monitored by the spindle checkpoint, a surveillance mechanism preventing the cell from prematurely entering anaphase. The adenomatous polyposis coli (Apc) gene also plays an important role in regulating genomic stability, as mutations of Apc cause aneuploidy. Here we show that...
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