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Article

Pathophysiological consequences of isoform-specific IP3 receptor mutations.

Biochimica et biophysica acta. Molecular cell research - 1 Nov 2018

Kerkhofs Martijn, Seitaj Bruno, Ivanova Hristina, Monaco Giovanni, Bultynck Geert, Parys Jan B

Abstract excerpt

Ca2+ signaling governs a diverse range of cellular processes and, as such, is subject to tight regulation. A main component of the complex intracellular Ca2+-signaling network is the inositol 1,4,5-trisphosphate (IP3) receptor (IP3R), a tetrameric channel that mediates Ca2+ release from the endoplasmic reticulum (ER) in response to IP3. IP3R function is controlled by a myriad of factors, such as Ca2+, ATP,...

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PMID: 29906486
DOI: 10.1016/j.bbamcr.2018.06.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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