Article
Different sensitivities of bromodomain factors 1 and 2 to histone H4 acetylation.
Molecular cell - 1 Feb 2003
Matangkasombut Oranart, Buratowski Stephen
Abstract excerpt
The histone code hypothesis proposes that covalently modified histone tails are binding sites for specific proteins. In vitro evidence suggests that factors containing bromodomains read the code by binding acetylated histone tails. Bromodomain Factor 1 (Bdf1), a protein that associates with TFIID, binds histone H4 with preference for multiply acetylated forms. In contrast, the closely related protein Bdf2 shows...
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