Article
Genetic background determines the extent of atherosclerosis in ApoE-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 1999
Dansky H M, Charlton S A, Sikes J L, Heath S C, Simantov R, Levin L F, Shu P, Moore K J, Breslow J L, Smith J D
Abstract excerpt
Two strains of ApoE-deficient mice were found to have markedly different plasma lipoprotein profiles and susceptibility to atherosclerosis when fed either a low-fat chow or a high-fat Western-type diet. FVB/NJ ApoE-deficient (FVB E0) mice had higher total cholesterol, HDL cholesterol, ApoA1, and ApoA2 levels when compared with C57BL/6J ApoE-deficient (C57 E0) mice. At 16 weeks of age, mean aortic root...
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