Article
Apolipoprotein A-I protection against atherosclerosis is dependent on genetic background.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2014
Sontag Timothy J, Krishack Paulette A, Lukens John R, Bhanvadia Clarissa V, Getz Godfrey S, Reardon Catherine A
Abstract excerpt
OBJECTIVE: Inbred mouse strains have different susceptibilities to experimental atherosclerosis. The C57BL/6 strain is among the most sensitive and has, therefore, been the most widely used in atherosclerosis studies, whereas many strains are resistant. The FVB/N strain is highly resistant to atherosclerosis on the apolipoprotein E (apoE)- and low-density lipoprotein (LDL) receptor-deficient backgrounds....
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