Article
HLA-DP allele-specific T cell responses to beryllium account for DP-associated susceptibility to chronic beryllium disease.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2001
Lombardi G, Germain C, Uren J, Fiorillo M T, du Bois R M, Jones-Williams W, Saltini C, Sorrentino R, Lechler R
Abstract excerpt
Occupational exposure to small molecules, such as metals, is frequently associated with hypersensitivity reactions. Chronic beryllium (Be) disease (CBD) is a multisystem granulomatous disease that primarily affects the lung, and occurs in approximately 3% of individuals exposed to this element. Immunogenetic studies have demonstrated a strong association between CBD and possession of alleles of HLA-DP containing...
Topics
- Alleles
- Amino Acid Substitution
- Animals
- Berylliosis
- Beryllium
- Cell Culture Techniques
- Cell Line, Transformed
- Chronic Disease
- Clone Cells
- Cytokines
- Epitopes, T-Lymphocyte
- Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor