Article
Impact of negatively charged patches on the surface of MHC class II antigen-presenting proteins on risk of chronic beryllium disease.
Journal of the Royal Society, Interface - 6 Jul 2008
Snyder James A, Demchuk Eugene, McCanlies Erin C, Schuler Christine R, Kreiss Kathleen, Andrew Michael E, Frye Bonnie L, Ensey James S, Stanton Marcia L, Weston Ainsley
Abstract excerpt
Chronic beryllium disease (CBD) is a granulomatous lung disease that occurs primarily in workers who are exposed to beryllium dust or fumes. Although exposure to beryllium is a necessary factor in the pathobiology of CBD, alleles that code for a glutamic acid residue at the 69th position of the HLA-DPbeta1 gene have previously been found to be associated with CBD. To date, 43 HLA-DPbeta1 alleles that code for...
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