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Ile-Leu Substitution (I415L) in Germline E-cadherin Gene (CDH1) in Japanese Familial Gastric Cancer

1 Jan 2003

Abstract excerpt

BACKGROUND: Germline mutation in the cell adhesion molecule E-cadherin is known to be associated with the development of undifferentiated or diffuse-type familial gastric cancers, but the prevalence of this contribution seems to be low in Japanese familial cases, so far. METHODS: We screened all exons of the E-cadherin gene for mutations in 101 Japanese patients having an intense family history of gastric...

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PMID: 12604719
DOI: 10.1093/jjco/hyg002

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