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Mutation screen and RNA analysis disclose the changed splicing of the E-cadherin transcription in gastric cancer.

Familial cancer - 1 Sept 2013

Li Xiaowei, Gao Yafan, Pan Yiyuan, Pan Yan, Wang Lifeng, Xiao Nong, He Qiong, Fan Yimei, Wang Yaping

Abstract excerpt

Gastric cancer (GC) is considered to be one of the leading cancers in East Asians, and mutations in the CDH1 gene and the reduced expression of E-cadherin are the most frequent genetic alterations in gastric cancer. In this paper, we reported two novel germline CDH1 nonsynonymous mutations, c.1296 C>G (N432 K) and c.1297 G>A (D433 N) detected in sporadic Chinese GC patients. RNA splicing analysis was used to...

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Source

Identifiers

PMID: 23435907
DOI: 10.1007/s10689-013-9619-x

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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