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Article

[Germline E-cadherin gene mutation screening in familial gastric cancer kindreds].

Zhonghua wai ke za zhi [Chinese journal of surgery] - 7 Aug 2004

Jiang Yong, Wan Yuan-Lian, Wang Zhen-Jun, Zhao Bo, Zhu Jing, Huang Yan-Ting

Abstract excerpt

OBJECTIVE: To evaluate the frequency and nature of E-cadherin gene (CDH1) germline mutations in familial gastric cancer kindreds of china. METHODS: Five familial gastric cancer kindreds of Chinese origin were screened for germline CDH1 mutations, all of them meeting the clinical criteria for hereditary diffuse gastric cancer (HDGC), by PCR-DHPLC and direct sequencing. RESULTS: A new truncating mutation in exon 10...

Topics

Adult
Breast Neoplasms
Cadherins
Female
Humans
Male
Middle Aged
Mutation
Neoplasms, Multiple Primary
Neoplastic Syndromes, Hereditary
Pedigree

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Stomach Neoplasms

Source

Identifiers

PMID: 15363252

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15363252-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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