E-cadherin germline mutations in familial gastric cancer.

doi:10.1038/32918

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Article

E-cadherin germline mutations in familial gastric cancer.

Nature - 26 Mar 1998

Guilford P, Hopkins J, Harraway J, McLeod M, McLeod N, Harawira P, Taite H, Scoular R, Miller A, Reeve A E

Abstract excerpt

The identification of genes predisposing to familial cancer is an essential step towards understanding the molecular events underlying tumorigenesis and is critical for the clinical management of affected families. Despite a declining incidence, gastric cancer remains a major cause of cancer deat...

Topics

Adolescent
Adult
Aged
Cadherins
Child
Child, Preschool
DNA Mutational Analysis
Female
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Infant
Infant, Newborn
Male
Middle Aged
Pedigree

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