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<i>CDH1</i>/E-cadherin germline mutations in early-onset gastric cancer

26 Jun 2006

Abstract excerpt

BACKGROUND: Gastric cancer remains a leading cause of cancer deaths worldwide. Genetic factors, including germline mutations in E-cadherin (CDH1, MIM#192090) in hereditary diffuse gastric cancer (HDGC, MIM#137215), are implicated in this disease. Family studies have reported CDH1 germline mutations in HDGC but the role of CDH1 germline mutations in the general population remains unclear. AIMS: To examine the...

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PMID: 16801346
DOI: 10.1136/jmg.2006.043133

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