Article
Germline alterations in the CDH1 gene in familial gastric cancer in the Japanese population.
Cancer science - 1 Oct 2011
Yamada Hidetaka, Shinmura Kazuya, Ito Hiroaki, Kasami Masako, Sasaki Naomi, Shima Hideyuki, Ikeda Masami, Tao Hong, Goto Masanori, Ozawa Takachika, Tsuneyoshi Toshihiro, Tanioka Fumihiko, Sugimura Haruhiko
Abstract excerpt
Germline point or small frameshift mutations of the CDH1 (E-cadherin) gene are known to cause familial gastric cancer (FGC), but the frequency of CDH1 mutations is low in Japanese patients with FGC. Because recent studies have reported germline large genomic deletions of CDH1 in European and Cana...
Topics
- Animals
- Antigens, CD
- Base Sequence
- CHO Cells
- Cadherins
- Cell Adhesion
- Cell Line
- Cricetinae
- Frameshift Mutation
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Japan
- Sequence Analysis, DNA