Article
Searching for E-cadherin gene mutations in early onset diffuse gastric cancer and hereditary diffuse gastric cancer in Korean patients.
Familial cancer - 1 Sept 2013
Kim Sollip, Chung Jun-Won, Jeong Tae-Dong, Park Young-Soo, Lee Jeong Hoon, Ahn Ji Yong, Kim Do Hoon, Choi Kee Don, Lee Woochang, Song Ho June, Lee Gin Hyug, Chun Sail, Jung Hwoon-Yong, Min Won-Ki, Kim Jin-Ho
Abstract excerpt
The impact of CDH1 gene mutations and large deletions on hereditary diffuse gastric cancer (HDGC) and early onset diffuse gastric cancer (EODGC) has not been determined in Asians. We investigated the mutation status of the CDH1 gene in 25 Korean EODGC patients younger than 50 years and 23 HDGC patients who met the clinical criteria for HDGC. Polymerase chain reaction-direct sequencing was performed, and multiplex...
Topics
- Adenocarcinoma
- Adult
- Antigens, CD
- Cadherins
- Female
- Follow-Up Studies
- Gene Deletion
- Genetic Predisposition to Disease
- Humans
- Immunoenzyme Techniques