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Article

Germline mutation of the E-cadherin gene in three sibling cases with advanced gastric cancer: clinical consequences for the other family members.

European journal of gastroenterology & hepatology - 1 Mar 2010

Mayrbaeurl Beate, Keller Gisela, Schauer Walter, Burgstaller Sonja, Czompo Manfred, Hoebling Walter, Knoflach Peter, Duba Hans C, Hoefler Heinz, Thaler Josef

Abstract excerpt

BACKGROUND AND AIMS: Germline mutations in the E-cadherin (CDH1) gene have been found in families with hereditary diffuse gastric cancer (HDGC). These families are characterized by a highly penetrant susceptibility to diffuse gastric cancer with an autosomal dominant pattern of inheritance. We describe the clinical presentation of three sibling cases with advanced gastric cancer, the way of confirming the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19474748
DOI: 10.1097/MEG.0b013e32832bab9a

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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