Article
Germline mutation of the E-cadherin gene in three sibling cases with advanced gastric cancer: clinical consequences for the other family members.
European journal of gastroenterology & hepatology - 1 Mar 2010
Mayrbaeurl Beate, Keller Gisela, Schauer Walter, Burgstaller Sonja, Czompo Manfred, Hoebling Walter, Knoflach Peter, Duba Hans C, Hoefler Heinz, Thaler Josef
Abstract excerpt
BACKGROUND AND AIMS: Germline mutations in the E-cadherin (CDH1) gene have been found in families with hereditary diffuse gastric cancer (HDGC). These families are characterized by a highly penetrant susceptibility to diffuse gastric cancer with an autosomal dominant pattern of inheritance. We de...
Topics
- Antigens, CD
- Cadherins
- Carcinoma, Signet Ring Cell
- Chemotherapy, Adjuvant
- Chromatography, High Pressure Liquid
- DNA Mutational Analysis
- Exons
- Fatal Outcome
- Female
- Gastrectomy
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans