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Article

The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2003

Amano Hirofumi, Amano Eri, Moll Thomas, Marinkovic Dragan, Ibnou-Zekri Nabila, Martinez-Soría Eduardo, Semac Isabelle, Wirth Thomas, Nitschke Lars, Izui Shozo

Abstract excerpt

The accelerated development of systemic lupus erythematosus (SLE) in BXSB male mice is associated with the presence of an as yet unidentified mutant gene, Yaa (Y-linked autoimmune acceleration). In view of a possible role of marginal zone (MZ) B cells in murine SLE, we have explored whether the expression of the Yaa mutation affects the differentiation of MZ and follicular B cells, thereby implicating the...

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PMID: 12594250
DOI: 10.4049/jimmunol.170.5.2293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells.PMID 12594250Read ↗

Lessons from BXSB and related mouse models.Semantic proximity Read ↗

Differential activation of anti-erythrocyte and anti-DNA autoreactive B lymphocytes by the Yaa mutation.Semantic proximity Read ↗

Hyperproliferation of BXSB B cells is linked to the Yaa allele.Semantic proximity Read ↗

Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus.Semantic proximity Read ↗

Evidence that Yaa-induced loss of marginal zone B cells is a result of dendritic cell-mediated enhanced activation.Semantic proximity Read ↗

BXSB-type genome causes murine autoimmune glomerulonephritis: pathological correlation between telomeric region of chromosome 1 and Yaa.Semantic proximity Read ↗

Autoreactive marginal zone B cells enter the follicles and interact with CD4+ T cells in lupus-prone miceSemantic proximity Read ↗

Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus.Semantic proximity Read ↗

Lupus resistance is associated with marginal zone abnormalities in an NZM murine model.Semantic proximity Read ↗

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The <i>Yaa</i> Locus and IFN-α Fine-Tune Germinal Center B Cell Selection in Murine Systemic Lupus ErythematosusSemantic proximity Read ↗

The lupus-prone NZM2410/NZW strain-derived Sle1b sublocus alters the germinal center checkpoint in female mice in a B cell-intrinsic manner.Semantic proximity Read ↗

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