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Article

Evidence that Yaa-induced loss of marginal zone B cells is a result of dendritic cell-mediated enhanced activation.

Journal of autoimmunity - 1 Jun 2010

Santiago-Raber Marie-Laure, Amano Hirofumi, Amano Eri, Fossati-Jimack Liliane, Swee Lee Kim, Rolink Antonio, Izui Shozo

Abstract excerpt

The development of systemic lupus is accelerated by the Yaa (Y-linked autoimmune acceleration) mutation, which is the consequence of a translocation of the telomeric end containing the Tlr7 gene from the X chromosome onto the Y chromosome. However, the loss of marginal zone (MZ) B cells, one of the Yaa-linked cellular abnormalities, has previously been shown to be unrelated to the Tlr7 gene duplication, and the...

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Source

Identifiers

PMID: 20149596
DOI: 10.1016/j.jaut.2010.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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