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Article

The lupus-prone NZM2410/NZW strain-derived Sle1b sublocus alters the germinal center checkpoint in female mice in a B cell-intrinsic manner.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2012

Wong Eric B, Khan Tahsin N, Mohan Chandra, Rahman Ziaur S M

Abstract excerpt

C57BL/6 (B6) mice carrying the Sle1b sublocus (named B6.Sle1b), which harbors the lupus-associated NZM2410/NZW SLAM family genes, produce antinuclear Abs (ANAs). However, the role and mechanism(s) involved in the alteration of the germinal center (GC) tolerance checkpoint in the development of ANAs in these mice is not defined. In this study, we show significantly higher spontaneously formed GCs (Spt-GCs) in...

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Identifiers

PMID: 23144494
DOI: 10.4049/jimmunol.1201661
PMCID: PMC3518623

Genes

CXCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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