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Article

Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2008

Santiago-Raber Marie-Laure, Kikuchi Shuichi, Borel Paula, Uematsu Satoshi, Akira Shizuo, Kotzin Brian L, Izui Shozo

Abstract excerpt

The accelerated development of systemic lupus erythematosus (SLE) in male BXSB mice is associated with the genetic abnormality in its Y chromosome, designated Yaa (Y-linked autoimmune acceleration). Recently, the Yaa mutation was identified to be a translocation from the telomeric end of the X chromosome (containing the gene encoding TLR7) onto the Y chromosome. In the present study, we determined whether the...

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Share to Antibodies, Antinuclear
Share to Gene Duplication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lupus Erythematosus, Systemic

Share to Mice, Congenic

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Share to Toll-Like Receptor 7

Share to Translocation, Genetic

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Source

Identifiers

PMID: 18606711
DOI: 10.4049/jimmunol.181.2.1556

Genes

TLR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus.PMID 18606711Read ↗

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Interferon-alpha treatment of female (NZW x BXSB)F(1) mice mimics some but not all features associated with the Yaa mutation.Semantic proximity Read ↗

The Yaa gene model of systemic lupus erythematosus.Semantic proximity Read ↗

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Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice.Semantic proximity Read ↗

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