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Article

Hyperproliferation of BXSB B cells is linked to the Yaa allele.

Clinical immunology and immunopathology - 1 Nov 1996

DesJardin L E, Butfiloski E J, Sobel E S, Schiffenbauer J

Abstract excerpt

Systemic lupus erythematosus is characterized by polyclonal B cell activation, the production of autoantibodies, and often by renal disease. Previous studies demonstrated that unfractionated B cells from several strains of mice with lupus hyperproliferate in culture when stimulated with lipopolysaccharide (LPS) or anti-IgM. We wished to further examine proliferation of resting B cells from the BXSB mouse model of...

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Identifiers

PMID: 8906745
DOI: 10.1006/clin.1996.0170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Hyperproliferation of BXSB B cells is linked to the Yaa allele.PMID 8906745Read ↗

The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells.Semantic proximity Read ↗

Lessons from BXSB and related mouse models.Semantic proximity Read ↗

BXSB-type genome causes murine autoimmune glomerulonephritis: pathological correlation between telomeric region of chromosome 1 and Yaa.Semantic proximity Read ↗

Immunological abnormalities in BXSB mice at the onset of SLE development.Semantic proximity Read ↗

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Differential activation of anti-erythrocyte and anti-DNA autoreactive B lymphocytes by the Yaa mutation.Semantic proximity Read ↗

Interferon-alpha treatment of female (NZW x BXSB)F(1) mice mimics some but not all features associated with the Yaa mutation.Semantic proximity Read ↗

Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus.Semantic proximity Read ↗

Treatment of BXSB‐<i>Yaa</i> Mice with IL‐21R‐Fc Fusion Protein Minimally Attenuates Systemic Lupus ErythematosusSemantic proximity Read ↗

Chronic BCR signaling generates and maintains age-associated B cells from anergic B cellsSemantic proximity Read ↗

Fas and Fas ligand mutations inhibit autoantibody production in pristane-induced lupus.Semantic proximity Read ↗

Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus.Semantic proximity Read ↗

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