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Article

Autoreactive marginal zone B cells enter the follicles and interact with CD4+ T cells in lupus-prone mice

20 Jan 2011

Abstract excerpt

BACKGROUND: Marginal zone B cells have been implicated in the production of autoantibodies in murine models of lupus. It has been suggested that they contribute to lupus immunopathogenesis through their enhanced effector functions and their repertoire that is biased toward autoreactive specificities. In the B6.NZM2410.Sle.Sle2.Sle3 (B6.TC) model of lupus, the majority of marginal zone B cells are located outside...

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PMID: 21251257
DOI: 10.1186/1471-2172-12-7

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