Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BXSB-type genome causes murine autoimmune glomerulonephritis: pathological correlation between telomeric region of chromosome 1 and Yaa.

Genes and immunity - 1 Jan 2000

Kimura J, Ichii O, Nakamura T, Horino T, Otsuka S, Kon Y

Abstract excerpt

The autoimmune-prone BXSB/MpJ-Yaa mouse is a model of membranous proliferative glomerulonephritis (MPGN). Severe MPGN has been reported only in male BXSB/MpJ-Yaa mice because of the Y-linked autoimmune accelerator (Yaa) locus. However, we show that female BXSB/MpJ mice develop age-related MPGN without Yaa. Female BXSB/MpJ mice clearly developed MPGN characterized by increased mesangial cells, thickening of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune Diseases
Share to Chromosomes, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glomerulonephritis

Share to Kidney Function Tests

Share to Kidney Glomerulus

Share to Podocytes

Share to Telomere

Share to Y Chromosome

Source

Identifiers

PMID: 24477164
DOI: 10.1038/gene.2014.4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BXSB-type genome causes murine autoimmune glomerulonephritis: pathological correlation between telomeric region of chromosome 1 and Yaa.PMID 24477164Read ↗

Interferon-alpha treatment of female (NZW x BXSB)F(1) mice mimics some but not all features associated with the Yaa mutation.Semantic proximity Read ↗

Multiple lupus susceptibility loci map to chromosome 1 in BXSB mice.Semantic proximity Read ↗

Castrated autoimmune glomerulonephritis mouse model shows attenuated glomerular sclerosis with altered parietal epithelial cell phenotype.Semantic proximity Read ↗

Deletion of the antiphospholipid syndrome autoantigen β2 -glycoprotein I potentiates the lupus autoimmune phenotype in a Toll-like receptor 7-mediated murine model.Semantic proximity Read ↗

Interferon-inducible Ifi200-family genes as modifiers of lupus susceptibility.Semantic proximity Read ↗

Lessons from BXSB and related mouse models.Semantic proximity Read ↗

Overexpression of interferon-activated gene 202 (Ifi202) correlates with the progression of autoimmune glomerulonephritis associated with the MRL chromosome 1.Semantic proximity Read ↗

The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells.Semantic proximity Read ↗

Differential role of three major New Zealand Black-derived loci linked with Yaa-induced murine lupus nephritis.Semantic proximity Read ↗

New insights into disease pathogenesis from mouse lupus genetics.Semantic proximity Read ↗

Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus.Semantic proximity Read ↗

Genome-wide scan in a novel IgA nephropathy model identifies a susceptibility locus on murine chromosome 10, in a region syntenic to human IGAN1 on chromosome 6q22-23.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.