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Article

SOD2 functions downstream of Sch9 to extend longevity in yeast.

Genetics - 1 Jan 2003

Fabrizio Paola, Liou Lee-Loung, Moy Vanessa N, Diaspro Alberto, Valentine Joan Selverstone, Gralla Edith Butler, Longo Valter D

Abstract excerpt

Signal transduction pathways inactivated during periods of starvation are implicated in the regulation of longevity in organisms ranging from yeast to mammals, but the mechanisms responsible for life-span extension are poorly understood. Chronological life-span extension in S. cerevisiae cyr1 and sch9 mutants is mediated by the stress-resistance proteins Msn2/Msn4 and Rim15. Here we show that mitochondrial...

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Identifiers

PMID: 12586694
DOI: 10.1093/genetics/163.1.35
PMCID: PMC1462415

Genes

SOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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