Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells.

Abstract excerpt

Mutations in Ras and other signal transduction proteins increase survival and resistance to oxidative stress and starvation in stationary phase yeast, nematodes, fruit flies, and in neuronal PC12 cells. The chronological life span of yeast, based on the survival of nondividing cells in stationary phase, has allowed the identification and characterization of long-lived strains with mutations in the G-protein Ras2....

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