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Article

Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.

PloS one - 30 Jul 2008

Zuin Alice, Gabrielli Natalia, Calvo Isabel A, García-Santamarina Sarela, Hoe Kwang-Lae, Kim Dong Uk, Park Han-Oh, Hayles Jacqueline, Ayté José, Hidalgo Elena

Abstract excerpt

BACKGROUND: Oxidative stress is a probable cause of aging and associated diseases. Reactive oxygen species (ROS) originate mainly from endogenous sources, namely the mitochondria. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed the effect of aerobic metabolism on oxidative damage in Schizosaccharomyces pombe by global mapping of those genes that are required for growth on both respiratory-proficient media and...

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Identifiers

PMID: 18665268
DOI: 10.1371/journal.pone.0002842
PMCID: PMC2475502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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