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Article

Growth phase-dependent roles of Sir2 in oxidative stress resistance and chronological lifespan in yeast.

Journal of microbiology (Seoul, Korea) - 1 Aug 2014

Kang Woo Kyu, Kim Yeong Hyeock, Kim Byoung-Soo, Kim Jeong-Yoon

Abstract excerpt

Silent Information Regulator 2 (Sir2), a conserved NAD(+)-dependent histone deacetylase, has been implicated as one of the key factors in regulating stress response and longevity. Here, we report that the role of Sir2 in oxidative stress resistance and chronological lifespan is dependent on growth phase in yeast. In exponential phase, sir2Δ cells were more resistant to H2O2 stress and had a longer chronological...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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PMID: 24997552
DOI: 10.1007/s12275-014-4173-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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