Article
Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae.
The Journal of cell biology - 27 Sept 2004
Fabrizio Paola, Battistella Luisa, Vardavas Raffaello, Gattazzo Cristina, Liou Lee-Loung, Diaspro Alberto, Dossen Janis W, Gralla Edith Butler, Longo Valter D
Abstract excerpt
Aging is believed to be a nonadaptive process that escapes the force of natural selection. Here, we challenge this dogma by showing that yeast laboratory strains and strains isolated from grapes undergo an age- and pH-dependent death with features of mammalian programmed cell death (apoptosis). After 90-99% of the population dies, a small mutant subpopulation uses the nutrients released by dead cells to grow....
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