Article

Genetically controlled mtDNA editing prevents ROS damage by arresting oxidative phosphorylation

2020-11-20

Abstract excerpt

Deletion of mitochondrial DNA in eukaryotes is mainly attributed to rare accidental events associated with mitochondrial replication or repair of double-strand breaks. We report the discovery that yeast cells arrest harmful intramitochondrial superoxide production by shutting down respiration through genetically controlled deletion of mitochondrial oxidative phosphorylation genes. We show that the regulatory circu...

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Identifiers and source

Literature Corpus work: 19c48333-584a-5a60-a42f-2b9751f576cc
DOI: 10.1101/2020.11.20.391110

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