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Article

Regulation of longevity and stress resistance by Sch9 in yeast.

Science (New York, N.Y.) - 13 Apr 2001

Fabrizio P, Pozza F, Pletcher S D, Gendron C M, Longo V D

Abstract excerpt

The protein kinase Akt/protein kinase B (PKB) is implicated in insulin signaling in mammals and functions in a pathway that regulates longevity and stress resistance in Caenorhabditis elegans. We screened for long-lived mutants in nondividing yeast Saccharomyces cerevisiae and identified mutations in adenylate cyclase and SCH9, which is homologous to Akt/PKB, that increase resistance to oxidants and extend...

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Source

Identifiers

PMID: 11292860
DOI: 10.1126/science.1059497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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