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Article

Reduced mitochondrial SOD displays mortality characteristics reminiscent of natural aging.

Mechanisms of ageing and development - 1 Jan 2000

Paul Anirban, Belton Amy, Nag Sanjay, Martin Ian, Grotewiel Michael S, Duttaroy Atanu

Abstract excerpt

Manganese superoxide dismutase (MnSOD or SOD2) is a key mitochondrial enzymatic antioxidant. Arguably the most striking phenotype associated with complete loss of SOD2 in flies and mice is shortened life span. To further explore the role of SOD2 in protecting animals from aging and age-associated pathology, we generated a unique collection of Drosophila mutants that progressively reduce SOD2 expression and...

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Identifiers

PMID: 18078670
DOI: 10.1016/j.mad.2007.10.013
PMCID: PMC2675272

Genes

SOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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