Article
Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9.
PLoS genetics - 1 Jan 2008
Wei Min, Fabrizio Paola, Hu Jia, Ge Huanying, Cheng Chao, Li Lei, Longo Valter D
Abstract excerpt
Calorie restriction (CR), the only non-genetic intervention known to slow aging and extend life span in organisms ranging from yeast to mice, has been linked to the down-regulation of Tor, Akt, and Ras signaling. In this study, we demonstrate that the serine/threonine kinase Rim15 is required for yeast chronological life span extension caused by deficiencies in Ras2, Tor1, and Sch9, and by calorie restriction....
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