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Article

Oncogenic potential of a dominant negative mutant of interferon regulatory factor 3.

The Journal of biological chemistry - 25 Apr 2003

Kim Tae Young, Lee Kyoung-Hu, Chang Seungwoo, Chung Cheolho, Lee Han-Woong, Yim Jeongbin, Kim Tae Kook

Abstract excerpt

Interferon regulatory factor 3 (IRF3) is activated in response to various environmental stresses including viral infection and DNA-damaging agents. However, the biological function of IRF3 in cell growth is not well understood. We demonstrated that IRF3 markedly inhibited growth and colony formation of cells. IRF3 blocked DNA synthesis and induced apoptosis. Based on this negative control of cell growth by IRF3,...

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Identifiers

PMID: 12582166
DOI: 10.1074/jbc.M205792200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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